This site is intended for US Healthcare Professionals Only

Prescribing Information
Important Safety Information
Acquia CMS logo

SnakeBite911 App

SnakeBite 911 Logo

SnakeBite911 App

The SnakeBite911 app can educate you about North American pit vipers, help you track the progression of an envenomation, and let you know what to do (and what NOT to do) in the event of a snakebite.

Potentially life-saving tips, tools, and resources for:

First responder icon

First Responders

Emergency room healthcare professional icon

Emergency Room Healthcare Professionals

Emergency room healthcare professional icon

Outdoor Enthusiasts

Image of phones showings pit viper facts and reconstitution and administration of CroFab from the SnakeBite911 App
Apple Store icon
Google Play icon

Be Knowledgeable

  • Find facts about North American pit vipers and how to identify them
  • Access tips on how to keep safe from snakes and avoid being bitten
  • Easily search for snakes that live in your state
  • Review CroFab® Crotalidae Polyvalent Immune Fab (Ovine) Important Safety Information and Prescribing Information
  • Watch the CroFab Reconstitution and Administration video
Apple Store icon
Google Play icon

Get Help

  • Quickly dial 911 or the Poison Center at (800) 222-1222
  • Utilize the time-stamped venom tracker tool with timed reminders to capture venom progression, including the ability to add notes to photos
  • Access an interactive Unified Treatment Algorithm
  • View best practice steps for treatment and aftercare, including a checklist of steps to avoid when treating pit viper bites
Image of phone showing the prompt to photograph the leading edge of swelling from the SnakeBite911 App
Choose CroFab icon

CroFab: Strength and speed when you need it most

Choose CroFab
CroFab efficacy checkmark icon

CroFab is clinically proven to achieve initial control of envenomation 

Examine the Data
CroFab dosing vial icon

Appropriate dosing achieves initial and sustained control of envenomation 

Learn How to Dose CroFab
References

  1. CroFab®. Prescribing information. BTG International Inc.; August 2018.

Indication and Important Safety Information
Indication

CroFab® Crotalidae Polyvalent Immune Fab (Ovine) is a sheep-derived antivenin indicated for the management of adult and pediatric patients with North American crotalid envenomation. The term crotalid is used to describe the Crotalinae subfamily (formerly known as Crotalidae) of venomous snakes which includes rattlesnakes, copperheads and cottonmouths/water moccasins.

Important Safety Information
Contraindications

Do not administer CroFab® to patients with a known history of hypersensitivity to any of its components, or to papaya or papain unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available.

Warnings and Precautions

Coagulopathy: In clinical trials, recurrent coagulopathy (the return of a coagulation abnormality after it has been successfully treated with antivenin), characterized by decreased fibrinogen, decreased platelets, and elevated prothrombin time, occurred in approximately half of the patients studied; one patient required re-hospitalization and additional antivenin administration. Recurrent coagulopathy may persist for 1 to 2 weeks or more. Patients who experience coagulopathy due to snakebite should be monitored for recurrent coagulopathy for up to 1 week or longer. During this period, the physician should carefully assess the need for re-treatment with CroFab® and use of any type of anticoagulant or anti-platelet drug.

Hypersensitivity Reactions: Severe hypersensitivity reactions may occur with CroFab®. In case of acute hypersensitivity reactions, including anaphylaxis and anaphylactoid reactions, discontinue infusion and institute appropriate emergency treatment. Patients allergic to papain, chymopapain, other papaya extracts, or the pineapple enzyme bromelain may also have an allergic reaction to CroFab®. Follow-up all patients for signs and symptoms of delayed allergic reactions or serum sickness (e.g., rash, fever, myalgia, arthralgia).

Adverse Reactions

The most common adverse reactions (incidence ≥ 5% of subjects) reported in the clinical studies were urticaria, rash, nausea, pruritus and back pain. Adverse reactions involving the skin and appendages (primarily rash, urticaria, and pruritus) were reported in 12 of the 42 patients. Two patients had a severe allergic reaction (severe hives and a severe rash and pruritus) following treatment and one patient discontinued CroFab® due to an allergic reaction. Recurrent coagulopathy due to envenomation and requiring additional treatment may occur.

Please see full Prescribing Information.