3 Areas of Pathologic Impact
Initial Control Requires Addressing All 3 Areas of Pathologic Impact1,2
A single venom contains a wide array of toxins—necrotoxins, pre- and postsynaptic neurotoxins, and nephrotoxins, among others. This complexity, along with other biological factors, makes it difficult in clinical practice to predict specific effects of an individual envenomation.2,3
However, all envenomations can exhibit some or all of the following effects2,3:
|Pain and local soft tissue damage are the first symptoms of envenomation. Necrotoxins may produce clinical effects almost immediately postbite, resulting in tissue digestion and vascular permeability.|
|Vesiculations and Bullae|
|General systemic effects include:|
|Specific systemic effects include, but are not limited to:|
|The 3 hematologic effects of envenomation are:|
Watch Dr. Arnold discuss his experience with CroFab and why initial control is extremely important.
1. CroFab® [prescribing Information]. BTG International Inc.; August 2018. 2. Lavonas EJ, Ruha AM, Banner W, et al. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop. BMC Emerg Med. 2011;11:2. 3. Smith J, Bush S. Envenomations by reptiles in the United States. In: Mackessy SP, ed. Handbook of Venoms and Toxins of Reptiles. CRC Press;2010:475-488. 4. Lavonas EJ, Khatri V, Daugherty C, Bucher-Bartelson B, King T, Dart RC. Medically significant late bleeding after treated crotaline envenomation: a systematic review. Ann Emerg Med. 2014;63(1):71-78.