For US Healthcare Professionals Important Safety Information Full Prescribing Information

Why Choose CroFab?

CroFab Is the Only Antivenom Derived From Native US Pit Vipers to Treat Envenomations From All Species of North American Pit Vipers1

CroFab Meets WHO Guidelines for Effective Snake Antivenom2

According to the World Health Organization (WHO), an effective antivenom is one derived from clinically relevant snakes native to the geographic region in which the antivenom is used.2

CroFab is the only antivenom derived from geographically and clinically relevant US snakes for comprehensive coverage of all North American pit viper envenomations.1,2

Cotton Mouth/Water Moccasin icon
Cotton Mouth/Water Moccasin photo thumbnail

Water Moccasin

Mojave Rattlesnake icon
Mojave Rattlesnake photo thumbnail


Eastern Diamondback icon
Eastern Diamondback photo thumbnail


Western Diamondback icon
Western Diamondback photo thumbnail


Water Moccasin - Coiled

Water Moccasin

Mojave Rattlesnak Coiled


Eastern Diamondback
Eastern Diamondback - Coiled


Western Diamondback
Western Diamondback - Coiled for Strike


CroFab Was Engineered to Neutralize a Broad Range of Clinically Relevant Toxins1

A Comprehensive Venomics Approach

Four snake species were strategically chosen based on their unique venom fingerprints, which together provide comprehensive coverage across the diverse venom compositions of North American pit vipers.1,3

High-performance liquid chromatography is used to separate and identify individual components of venom to define a unique venomic fingerprint for each snake type.4,5

The venom fingerprints of the four US pit vipers used to engineer CroFab


Hear why Dr. Thomas Arnold and Dr. William Banner choose CroFab.


Hear how CroFab helped real patients.



CroFab efficacy checkmark icon

CroFab is clinically proven to achieve initial control of envenomation2

Examine the Data
IgG antibody icon

CroFab rapidly binds to and neutralizes venom toxins2

See the MOA
CroFab safety clipboard icon

CroFab safety is backed by more than 20 years of clinical experience2

View Safety Profile

1. CroFab®. Prescribing information. BTG International Inc.; August 2018. 2. WHO Expert Committee on Biological Standardization. WHO Technical Report Series, No. 1004, Annex 5; 2017. Accessed September 13, 2023. 3. Data on file. BTG International Inc. 4. Tasoulis T, Isbister GK. Toxins (Basel). 2017;9(9):290 5. Gutiérrez JM et al. [Erratum in: Nat Rev Dis Primers. 2017;3:17079]. Nat Rev Dis Primers. 2017;3:17063. 6. Strickland JL et al. Sci Rep. 2018;8(1):17622. 7. Riley BD et al. In: Nelson LS et al, eds. Goldfrank’s Toxicologic Emergencies. 9th ed. McGraw-Hill Professional; 2010. 8. Borja M et al. Toxins (Basel). 2018;10(1):35.