CroFab Is the Only Antivenom Derived From Native US Pit Vipers to Treat Envenomations From All Species of North American Pit Vipers1
CroFab Meets WHO Guidelines for Effective Snake Antivenom2
According to the World Health Organization (WHO), an effective antivenom is one derived from clinically relevant snakes native to the geographic region in which the antivenom is used.2
CroFab is the only antivenom derived from geographically and clinically relevant US snakes for comprehensive coverage of all North American pit viper envenomations.1,2
Cottonmouth/
Water Moccasin
Mojave
Rattlesnake
Eastern
Diamondback
Western
Diamondback
Cottonmouth/
Water Moccasin
Mojave
Rattlesnake
Eastern
Diamondback
Western
Diamondback
CroFab Was Engineered to Neutralize a Broad Range of Clinically Relevant Toxins1
A Comprehensive Venomics Approach
Four snake species were strategically chosen based on their unique venom fingerprints, which together provide comprehensive coverage across the diverse venom compositions of North American pit vipers.1,3
High-performance liquid chromatography is used to separate and identify individual components of venom to define a unique venomic fingerprint for each snake type.4,5
Jessica
Caitlyn
REFERENCES
1. CroFab®. Prescribing information. BTG International Inc.; August 2018. 2. WHO Expert Committee on Biological Standardization. WHO Technical Report Series, No. 1004, Annex 5; 2017. Accessed September 13, 2023. https://cdn.who.int/media/docs/default-source/biologicals/blood-products/document-migration/antivenomglrevwho_trs_1004_web_annex_5.pdf?sfvrsn=ef4b2aa5_3&download=true. 3. Data on file. BTG International Inc. 4. Tasoulis T, Isbister GK. Toxins (Basel). 2017;9(9):290 5. Gutiérrez JM et al. [Erratum in: Nat Rev Dis Primers. 2017;3:17079]. Nat Rev Dis Primers. 2017;3:17063. 6. Strickland JL et al. Sci Rep. 2018;8(1):17622. 7. Riley BD et al. In: Nelson LS et al, eds. Goldfrank’s Toxicologic Emergencies. 9th ed. McGraw-Hill Professional; 2010. 8. Borja M et al. Toxins (Basel). 2018;10(1):35.
