CroFab Rapidly Binds to and Neutralizes Venom Toxins1
Upon Administration, CroFab Gets to Work
CroFab is specifically designed to contain a spectrum of venom-specific Fab fragments targeting the range of complex toxins found in North American pit viper venoms.1
![Complex array of toxins in North American pit viper venom](/getmedia/ee610241-699b-4d86-b7fd-e29fa2ecf7ee/2-2-Envenomation_finv.gif)
Envenomation
North American pit viper venom contains a complex array of toxins that can result in a range of local, systemic, and/or hematologic effects2,3
![Venom-specific Fab fragments in CroFab neutralizing venom toxins](/getmedia/c42f29a3-cf2b-483c-904a-59923247c6c8/2-2-RapidNeutralization_finv.gif)
Rapid Neutralization
The small size of venom-specific protein (Fab) fragments permits a rapid, large volume of distribution into tissue, allowing faster neutralization of venom toxins4
![Rapid clearance of venom and Fab fragments of CroFab](/getmedia/952b5913-ebb4-4ce8-93f0-a6472b9163b8/2-2-RapidClearance_finv.gif)
Rapid Clearance
Small protein (Fab) fragments also permit faster clearance, allowing for decreased immune system recognition and low incidence of hypersensitivity4
![IgG antibody icon](/getmedia/30f0d0d4-52b1-488e-b2c5-ebe733bf7042/Icon-Binds.png)
A proven manufacturing process ensures only the most effective and highest quality venom-specific antibodies1,5
REFERENCES
1. CroFab®. Prescribing information. BTG International Inc.; August 2018. 2. Ruha AN, Kleinschmidt KC, Greene S, et al; ToxIC Snakebite Study Group. The epidemiology, clinical course, and management of snakebites in the North American Snakebite Registry. J Med Toxicol. 2017;13(4):309-320. 3. Gutiérrez JM, Calvete JJ, Habib AG, Harrison RA, Williams DJ, Warrell DA. Snakebite envenoming. [Erratum in: Nat Rev Dis Primers. 2017;3:17079]. Nat Rev Dis Primers. 2017;3:17063. 4. Laustsen AH, María Gutiérrez J, Knudsen C, et al. Pros and cons of different therapeutic antibody formats for recombinant antivenom development. Toxicon. 2018;146:151-175. 5. Data on file. BTG International Inc.