For US Healthcare Professionals Important Safety Information Full Prescribing Information

Efficacy of CroFab

CroFab Is Clinically Proven to Arrest Local Injury, Resolve Systemic Effects, and Reduce Hematologic Effects of Envenomation1

Clinically Proven to Achieve Initial and Clinically Relevant Control of North American Pit Viper Envenomation1

Graph showing 98% of patients achieved initial control of envenomation and 95% experienced a clinical response with CroFab


Based on 2 open-label trials with 42 patients with mild or moderate envenomation. Exclusion criteria for both trials included envenomation by copperhead snakes. In study 1, patients were given up to 2 doses of 4 vials each to gain initial control. In study 2, patients were given up to 2 doses of 6 vials each to gain initial control.1


Level 1 Evidence Specifically for Copperhead Envenomation3

CroFab Administration Resulted in Improved Limb Function Following Copperhead Envenomation3


Graph showing improvement in limb function over 28 days with CroFab compared with placebo

Clinically meaningful and statistically significant improvements in limb function at 7, 10, and 14 days following envenomation compared with placebo (P<0.05) for all 3 time points).3,4

PSFS, Patient-Specific Functional Scale.
Based on a double-blind, placebo-controlled trial with 74 patients with mild or moderate envenomation.
Patients with severe envenomation were excluded. Patients were given up to 2 doses of 6 vials each to gain initial control.3

Watch Dr. Rutherfoord Rose discuss using
CroFab to treat copperhead envenomation.

 

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CroFab safety is backed by more than 20 years of clinical experience1

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Appropriate dosing achieves initial and sustained control of envenomation1

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Real-world use supports improved outcomes with CroFab1

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REFERENCES

1. CroFab® [prescribing Information]. BTG International Inc.; August 2018. 2. Dart RC, Seifert SA, Carroll L, et al. Affinity-purified, mixed monospecific crotalid antivenom ovine fab for the treatment of crotalid venom poisoning. Ann Emerg Med. 1997;30(1):33-39. 3. Gerardo CJ, Quackenbush E, Lewis B, et al. The efficacy of crotalidae polyvalent immune fab (ovine) antivenom versus placebo plus optional rescue therapy on recovery from copperhead snake envenomation: a randomized, double-blind, placebo-controlled clinical trial. Ann Emerg Med. 2017;70(2):233-244. 4. Data on file. BTG International Inc. 5. Anderson VE, Gerardo CJ, Rapp-Olsson M, et al. Early administration of Fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients. Clin Toxicol. 2019;57(1):25-30. 6. Freiermuth CE, Lavonas EJ, Anderson VE, et al. Antivenom treatment is associated with fewer patients using opioids after copperhead envenomation. West J Emerg Med. 2019;20(3):497-505.