Time is her tissue image

What is CroFab®

CroFab® is the only antivenom derived exclusively from US snakes to treat all North American pit viper envenomations in adult and pediatric patients.1,2 98% of venomous snakebites in the United States are from the North American pit viper.3

Approved in 2000, CroFab® was designed to reduce the high incidence of hypersensitivity that occurred with previous antivenom therapy, and to provide a geographically relevant antivenom. In the years since, CroFab® has become the antivenom that healthcare professionals rely on for the treatment of North American pit viper envenomation.1,4

Treat With Confidence
  • Derived exclusively from native US snakes for comprehensive coverage of all US pit viper venoms1
  • A safety profile you can count on1
  • Included in unified consensus algorithm4

Hear why Dr. Thomas Arnold and Dr. William Banner choose CroFab®.

Shield with three snakes

Regardless of Snakebite Severity, Treat With CroFab® to*:

  • Halt local effects, such as edema and ecchymosis, and treat the source of the pain1
  • Resolve systemic effects, such as nausea, vomiting, dizziness, or tachycardia1
  • Reduce coagulation abnormalities, such as thrombocytopenia, hyperfibrinogenemia, and spontaneous bleeding1,5

*Efficacy determined using the snakebite severity score (SSS), a validated objective tool for the clinical evaluation of North American pit viper snakebite in adults. The total score reflects patient evaluation on 6 dimensions: cardiovascular system, local wound, gastrointestinal system, hematologic symptoms, pulmonary system, and central nervous system. The higher the total score, the more severe the snakebite.1

Mechanism of Action


CroFab® mechanism of action

For illustrative purposes only.

CroFab® consists of venom-specific Fab fragments of immunoglobulin G (IgG) that work by binding to and neutralizing venom toxins, facilitating their redistribution away from target tissues and their elimination from the body.1

How CroFab® Works

  • Venom-specific Fab binds and neutralizes venom toxins1
  • Facilitates venom toxin redistribution away from target tissues1
  • Facilitates venom toxin elimination from the body1

Understand how CroFab® is clinically proven to help halt envenomation.


1. CroFab® [prescribing Information]. BTG International Inc; January 2018. 2. Data on file. Conshohocken, PA; BTG International Inc. 2019. 3. Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th Annual Report. Clin Toxicol. 2017;55(10):1072-1252. 4. Lavonas EJ, Ruha AM, Banner W, et al. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop. BMC Emerg Med. 2011;11:2.5. 5. Dart RC, McNally J. Efficacy, safety, and use of snake antivenoms in the United States. Ann Emerg Med. 2001;37(2):181-188.